Indeed, IL-18 is more than an inducer of IFN-γ

The Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment

Background & Objective: In human malaria, genotype of cytokines affect immune system. The impact of genotype -137G/C in IL-18 and +874A/T in IFN-γ on the severity of malaria and the quality of treatment – as factors to form asymptomatic persons in endemic regions- has been investigated.Materials & Methods: 100 patients and 102 healthy persons were evaluated by Nested-PCR and thick blood fil...

An IFN-γ-IL-18 Signaling Loop Accelerates Memory CD8+ T Cell Proliferation

Rapid proliferation is one of the important features of memory CD8(+) T cells, ensuring rapid clearance of reinfection. Although several cytokines such as IL-15 and IL-7 regulate relatively slow homeostatic proliferation of memory T cells during the maintenance phase, it is unknown how memory T cells can proliferate more quickly than naïve T cells upon antigen stimulation. To examine antigen-sp...

IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells.

Interferon-γ (IFN-γ) production by natural killer (NK) cells and cytotoxic lymphocytes is a key component of innate and adaptive immune responses. Because inhibitor of κB-ζ (IκBζ), a Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) inducible transcription factor, regulates IFN-γ production in KG-1 cells, we tested IκBζ's role in the classic lymphocyte pathway of IL-12/IL-18-induced IFN-γ...

Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells.

Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine in the same concentration range did not induce the production of IL-12 at all. The stimulatory or inhibitory effects of histamine on cytokine production were all antagonized by H2 receptor antagonists ranitidine and famoti...

Histamine Is a Potent Inducer of IL-18 and IFN-g in Human Peripheral Blood Mononuclear Cells